Abstract: The experiment was performed on the isolated and cultured human arterial smooth muscle cells（HASMC） separated from the essential hypertensives.The effects of verapamil and nicardipine on the intracellular calcium of HASMC were investigated.The calcium transmembrane influx and intracellular releasing processes in ASMC of essential hypertensives have not been clearly defined,so the authors tried to evaluate and get the direct evidence of the effects of the above mentioned drugs on calcium transmitting and releasing in HASMC in vitro.The results are as follows:1.The total intracellular calcium of the essential hypertensives is much higher than that of the control group.And it has an obvious correlationship with the intracellular calcium cations.2.The two calcium channel blockers can significantly decrease the intracellular calcium in both groups.Verapamil has decreased the transmembrane influx of 45 Ca 2+ .Nicardipine mainly prevents the intracellular calcium releasing.