Abstract: This study was designed to investigate the effects of marine fish oil（FO） and cholesterol （Ch） on hypertensive target organs in salt loaded SHRsp.Thirty seven male SHRsp at 6 weeks of age were randomly divided into 3 groups:FO group （n=12）,given a diet containing 7.0% EPA+DHA（eicosapentaenoic acid+docosahexaenoic acid）;Ch group（n=12）,diet containing 2.0% cholesterol;and C group（n=13）as control.Body weight was measured weekly,and SBP was measured before and 6 weeks after the experiment.The pathological changes in the brain and kidney were observed.SBP in the FO and Ch groups was significantly lower than that in the C group 6 weeks after the experiment （C:34.4±1.4;FO:28.2±\1.9\;Ch:28.4±1.8 kPa）.Marine fish oil and cholesterol significantly reduced the total cerebral stroke rate （C:100%;FO:25%;Ch:58.3%） and prolonged the lifespan （C:\80.8\±5.8;FO:111.3±9.5;Ch:106.8±8.6 days）.There was no ischemic cerebral stroke in the FO group （C:\69.2%\;FO:0;Ch:58.3%） and fewer hemorrhagic cerebral strokes in the Ch group （C:84.6%;FO:25%;Ch:16.7%）.Cholesterol,however,aggravated pathological kidney changes （arteriosclerosis:C,\30.7%\;FO,0;Ch,\58.3%\）.