大蒜精油对实验性动脉粥样硬化过程中TXA<sub>2</sub>/PGI<sub>2</sub>,LPO的影响

大蒜精油对实验性动脉粥样硬化过程中TXA₂/PGI₂,LPO的影响

摘要: 复制家兔高脂血症和动脉粥样硬化（AS）模型，观察大蒜精油（EOG）对血液中血栓素／前列环素（TXA2／PGI2）、胆固醇（Ch）、低密度脂蛋白胆固醇（LDLc）、载脂蛋白B（ApoB）和脂质过氧化（LPO）以及对AS形成的影响。结果显示，EOG能防止TXA2／PGI2，Ch，LDLC，ApoB及丙二醇的升高并起到防止AS形成的作用。

Abstract: In the present study, a rabbit model of hyperlipidemia and atherosclerosis（AS） was made and the effects of essential oil of garlic （EOG） on blood thromboxane/prostacyclin （TXA2/PGI2 ）, cholesterol （Ch ）, LDL-cholesterol （LDLc ）, apolipoprotein B （Apo B） and the effects on lipoperoxidation and atherosclerotic plaque were investigated. The results indicated that EOG could inhibit the increases in blood levels of TXA2/PGI2 ,Ch,LDLc,Apo B and malondialdehyde （MDA） in AS rabbits and could prevent experimental atherosclerosis.