血管紧张素转换酶抑制剂对高血压胰岛素抗性的影响

Effects of ACEI Therapy on Insulin Resistance in Patients with Essential Hypertension

摘要: 采用血管紧张素转换酶抑制剂（卡托普利、依那普利、赖诺普利）治疗原发性高血压患者30例。剂量分别为12．5～37．5，5～15，10～30mg／　d，疗程4周，血压从治疗前171／106mmHg降到143／88mmHg。治疗后的血胰岛素水平、血胰岛素／葡萄糖比值均较治疗前明显降低（P＜0．05），显示有明显的改善胰岛素抗性效应。

Abstract: ACEI （captopril, enalapril and lisinopril ） were administered with dosages as 12. 537. 5 mg/d. 515 mg/d and 10~30 mg/d,respectively for 4 weeks in 30 patients with essential hypertension. The results showed that the blood pressure decreased from 171/106 mmHg to 143/88 mmHg （P＜0. 001 ）. The blood insulin level and the blood insulin/glucose ratio during glucose loading were significantly reduced, suggesting that ACEI improves the insulin-resistance in patients with essential hypertension.