美托洛尔逆转高血压性左心室肥厚的效应

Effects of Metoprolol on Reversal of Hypertensive Left Ventricular Hypertrophy

摘要: 观察368例高血压病患者美托洛尔治疗10周前后的血压、左室重量指数（LVMI）、左至壁平均厚度（MWTd）及心功能指标：左室对血分数（LVEF）、每博输出量（SV）、二尖瓣E／A峰速度比的变化。治疗后SBP、LVMI、PWTd比治疗前明显减少（P＜0．001）。SBP与LVMI呈正相关（r＝0．386）。心功能指标改善。提示美托洛尔降压的同时可使高血压性左心室肥厚逆转。

Abstract: Blood pressure, LVMI, PWTd, LVEF, SV and E/A ratio were evaluated in 368 hypertensive patients before and after 10 weeks treatment by metoprolol. After treatment SBP, LVMI and PWTd were obviously reduced. Indices of cardiac function were improved.