Abstract: Mean BP, lymphocytic intracellular free Ca2+,plasma Angiotensin Ⅱ. and left ventricular diastolic functionwere determined in patients with essential hypertension（stages Ⅰ, Ⅱ） before and after 4 weeks amlodipine treatment.The results showed: （1）MAP, Ca2+i and Ang Ⅱ were significantly reduced after treatment （P＜0. 05 ）; （2）Ieft ventricular diastolic function （E, A,and E/A ratio） were obviously improved （P＜ 0. 05 ） ; （3）the decrease in Ca2+i was positivelycorrelated with the decrease in MAP （r= 0. 597, P＜ 0. 05）;the decrease in Ang Ⅱ was also positively correlated with thedecrease in MAP （r= 0. 454, P＜0. 05 ）; the descrease inCa2+i was negatively correlated with the increase in E/A ratio （r= - 0. 483,P＜0. 05） ; the descrease level of Ang Ⅱ wasalso negatively correlated with the increase level of E/A ratio（r= - 0. 449, P＜0. 05 ）. It is suggested: the mechanisms ofantihypertensive effect and irnprovernent of left ventricular diastolic function by amlodipine,might be associated to inhibitionon Ang Ⅱ activity and normalization of intracellular calciummetabolism.