纳络酮抗心律失常的机制不依赖于拮抗外周内源性阿片肽

Antagonizing Peripheral Endogenous Opiate Peptides May Not Be The Antiarrhythmic Mechanism of Naloxone

摘要: 为研究纳酪酮（Nal）的抗心律失常机制，制备大鼠缺血性心律失常模型，观察静脉注射Nal与3种内源性阿片肽（EOP）抗血清及小脑延髓池注射Nal对缺血性心律失常的影响，发现静脉及小脑延髓池注射Nal均有抗心律失常作用，而静脉注射3种EOP抗血清均无抗心律失常作用。提示Nal的抗心律失常的机制不依赖于拮抗外周内源性阿片肽EOP，而可能具有中枢机制。

Abstract: To study the antiarrhythmic mechanism of naloxone（Nal）,we made an ischemic arrhythmia model by coronary artery ligation in SD rats. The effects of Nal（iv） and intracisternally（ic） and the effect of three endogenous opiate peptides（EOP）antiserums iv on ischemic arrhythmia were evaluated.Results showed that Nal iv and ic could inhibit ischemic arrhythmia but none of three types of EOP an tiserum given iv had this effect.Antiarrhythmic mechanism of naloxone seems to be not ascribed to the antagonizing Peripheral endogenous opiate peptides.