摘要: We detected PKC isoform gene expression in the heart and brain of SHR using Northern blot analysis.The resultss revealed significant increased levels of expression of the Ca²⁺-dependent isoforms PKC-Y in the cerebral cortex of 4 and 20 weeks SHR compared with WKY, while Ca²⁺-inde pendent isoforms PKC-e did not differ between SHR and WKY.Interestingly，in ventricular myocardium,there was a significant expression of the Ca²⁺-inde pendent isoform PKC-εin 4 and 20 weeks SHR compared with WKY.Ca²⁺-dependent PKC-Y may be mainly involved in the modulation of blood pressure in the level of the central nervous system,while Ca²⁺-independent PKC-εcould be related to the genetic myocardial hypertrophy.