动态血压监测分析缓释维拉帕米和培哚普利的降压特点

Antihypertensive Feature of Slow Released Verapamil and Perindopril Monitored by Ambulatory Blood Pressure Measurement

摘要: 采用3种血压测量方法［偶测血压（CBP），自测血压（SMBP），动态血压（ABPM）］对两组高血压病人进行2种缓释降压药比较（A组，缓释维拉帕米n=20；B组，培哚普利n=20）。结果提示，（1）治疗前，CBP与SMBP方法对血压的判断无差异，与ABPM方法比较有差别，治疗后，血压下降用3种方法比较，ABPM测量方法能明显区别夜间及白天血压变化，而CBP及SMBP方法则否。（2）用ABPM方法监测降压药物的效果，发现B组降低DBP强于A组，对SBP的降压两组药差异无显著性。

Abstract: Casual（CBP）,self（SMBP）and ambulatory（ABPM）measurement were used in this study to compare the efficacies of 2 slow release antihypertensive drugs（Group A-Isoptin SR（verapamil）n=20,Group B-Acertil（perindopril）n＝20） in hypertensive patients.The findings of this study indicate that:（1）Before treatment there is no difference of blood pressure determination between CBP and SMBP measurements,but there is a differcence between CBP,SMBP measurements and ABPM,After the treatment,ABPM method is able to find the difference of blcod pressure between day time and night time,while CBP and SMBP not;（2）ABPM method indicates the Acertil is more effective in lowering DBP than Ipsotin group,but no difference of reduction in SBP between two drug groups was found.Conclusion:ABPM method may precisely analyse the hourly changes in blood pressure.