Abstract: Aim\ To investigate the changement of AngⅡ, aldosterone and aldosterone synthetase in SHR.\ Methods\ In vitro the mesentery vessels were perfusion for determinated the AngⅡ（immumoassay method）,aldosterone（HPLC method）. Aldosterone synthetase（RTPCR and Southern blot method） in SHR Aorta.\ Results wre compared with Wistar rats.\ Results\ AngⅡ,aldosterone and its synthetase mRNA were elevated in the perfusion fluid and aorta tissue of SHR than the Wistar.\ Conclusion\ Aldosterone, as an important factor for hypertension, is demonstrated to be overproduced in mesemtry vasculature of SHR.\ The mRNA expression of aldosterone synthetase is up-regulated in aorta tissue of SHR.