Abstract: Aim\ To analyse insertion/deletion polymorphism of angiotensinconverting enzyme gene in ischemic stroke with hypertension and hypertensives.\ Methods\ A 278 bp I/D polymorphism in intron 16 of the ACE gene was examined by polymorphism chain reaction in a study of 117 ischemic stroke patients（80 cases accompanied with hypertension） and 100 hypertensives and 40 control subjects（age,sex matched each other）.\ WT5 HZResults\ The polymorphism of the ACE gene was categorized into three genotypes:two deletion alleles（genotype DD）,heterozygous alleles（genotype ID）,and two insertion alleles（genotype II）.\ The frequencies of DD genotype and D alleles in ischemic stroke patients（including hypertensive patients） were significantly higher than that in hypertensives and control subjects.\ There were no difference between hypertensives and control subjects.\ Conclusion\ The results suggest that the DD genotype is associated with ischemic storke,not with hypertension.\ D alleles may be a susceptible gene to stroke in Chinese.