Abstract: Aim\ To observe the effects of chronic salt loading on insulin resistance in salt sensitive individuals with normotension.\ Methods\ Twenty three cases of normotensive volunteers underwent a dietary salt protocol consisting of 3 days of balanced sodium diet（NaCl, 14 g/d）, 7 days of high sodium diet（NaCl, 23 g/d） and 7 days of low sodium diet（NaCl, 3 g/d） to determine salt sensitives（SS）,14 subjects were defined as nonsalt sensitive while 9 were salt sensitive. Oral glucose tolerance test（OGTT） and insulin release test（IRT） were performed before and after the high sodium diet period.\ Results\ In SS,with chronic salt loading, the fasting plasma insulin level was much higher and the insulin responses to OGTT increased than those in the NSS, the fasting insulin was 122±57 vs 74±17 μU/ml（P＜005） and the area under curves of insulin after IRT was 746±219 vs 390±124 μU·h -1 ·L -1 , P＜005, respectively. After salt loading, the glucose levels in 60 minutes OGTT and the area under curves of glucose in SS were higher than those in the balanced salt diet.\ Conclusion\ High salt loading increasing blood pressure in salt sensitive individuals with normotension.