Abstract: Objective\ To explore the relationship between genetic factors of hyperlipidemia and the clustering of cardiovascular risk factors. Methods\ Twenty six pedigrees including familial combined hyperlipidemia （15 families） with 93 members and familial hypercholesterolemia （11 families） with 94 members were recruited from Beijing suburb. To analysis the difference of clustering of cardiovascular risk factors between first relative and second relative by adopting genetic epidemiology methods. Results\ Among six risk factors including overweight, high SBP, high DBP, high level of apolipoproteinB（apoB）, high blood glucose and low high density lipoprotein cholesterol （HDLc）, the decreasing of the risk factors clustering was significant correlated with the decline of relationship coefficiency（ P＜ 0 01）. Conclusion\ The underlying genetic factors of hyperlipidemia play an important role in the clustering of cardiovascular risk factors.