Abstract: Objective\ To study the relation between hypertensive left ventricular hypertrophy （LVH） in very old people （＞80 y/o） with neuro hormonal factors and ventricular arrhythmias. Methods\ Measurements were made on the heart rate variation, renin（Ren）, angiotensin Ⅱ（AT Ⅱ）, aldosterone（Ald）, insulin（Ins）,Holter and ambulatory blood pressure monitor in 60 cases of 2 groups:30 cases with primary hypertension in very old people and LVH（group A）; 30 cases with simple primary hypertension in very old people （group B）. Results\ （1）There was no significant difference of AT Ⅱand renin among group A,B （ P ＞0 05）;（2）Ins and Ald value in group A was much higher than group B （P all＜0 01）;（3） Very lower frequency （VLF） and low frequency （LF）,LF/HF in group A were significantly higher than group B（ P ＜0 01,0 05,0 05,respectively）; （4）incidence of premature ventricular beats and myocardial ischemia in group A were higher than those in group B. Conclusions\ （1）Sympathetic nerve excitability in group A was greatly increased; （2） Hypertensive LVH were closely associated with Ald and Ins level, but not with AT Ⅱand Ren; （3） there was obvious correction between group A and premature ventricular beats and heart muscle ischemia.