Abstract: Objective\ To investigate the role of angiotensin Ⅱ receptors in metabolism of myocardial collagen. Methods\ The collagen volume fraction（CVF）, perivascular circumferential area（PVCA）, hydroproline concentration（HC）, ratio of collagen type Ⅰto type Ⅲ（Ⅰ/Ⅲ）,angiotensin Ⅱ（AngⅡ） content and the maximal binding capacity （Bmax） of ATRs were studied. The methods of radioimmunoassay（RIA）,biochemistry assay, and pathological examination were used. Results\ Ventricular myocardial CVF, PVCA, HC, Ⅰ/Ⅲ, AngⅡ and Bmax of ATRs in WKY rats were significantly higher than those in sham operation（SO）（ P ＜0 05 or P ＜0 01）,suggesting the collagen was abnormally accumulated in rats heart muscles. AngⅡ was positivily correlated with HC（r\-1=0 9045, P ＜0 01）. After treament of Irbesartan, All above parameter were reduced significantly（ P ＜0 05 or P ＜0 01）, abnormally accumulated collagen was disappeared. While after treament of CGP42112A,an ATR 2 antagonist, Bmax of ATRs was markedly decreased（ P ＜0 01）, but CVF, PVCA, HC,Ⅰ/Ⅲ, AngⅡ showed little changes（ P ＞0 05）. Conclusion\ Obvious hyperplasia of myocardial collagens and remodeling of collagen network occurred after pressure overload. Local produced AngⅡ involves in the process,it’s effects is mainly mediated by angiotensin Ⅱ 1 type receptor（ATR\-1）