血管紧张素转换酶基因型与卡托普利疗效的相关性研究

Correlation of Angiotensin Converting Enzyme Genes Type with the Effect Antihypertensive treatment by Captopril

摘要: 目的　研究原发性高血压患者ACE基因多态性分布与卡托普利疗效的相关性。方法　 133名原发性高血压患者按ACE基因多态性的II ,ID与DD型三种 ,同时服用卡托普利 2 5mgbid ,服药前后作动态血压监测 ,以观察在各种不同ACE基因多态性间的区别。结果　ID型患者在 2 4小时收缩压 ,白天收缩压及夜间收缩压的降低程度均较其它型为明显 (P <0 0 5 )。结论 :转换酶抑制剂的作用可能与ACE的基因类型有关

Abstract: Objective To study the correlation of angiotensin converting enzyme genes type with the effect of antihypertension treatment by captopril. Methods Angiotensin converting enzyme genes I/D polymorphism were examined by polymerase chain reaction（PCR） in 133 patients with essential hypertension. Ambulatory blood pressure was measured before and after taking captopril 25 mg bid for 4 weeks. Results The reduction in 24 hSBP,dSBP,and nSBP in ID genetype was greater than that in II or DD genetype（ P ＜0 05）. Conclusion Captopril is may be more appropriate for the hypertensive patients with fit ACE I/D gene type.