Abstract: Aim To observe the effects of ramipril on insulin sensitivity in hypertension. Method Thirty seven cases were treated with Ramipril 2.5～5 mg daily titrating by the level of BP. The fasting blood glucose and insulin levels were measured.\ Insulin sensitivity index（ISI） was calculated before and after treatment. Twenty healthy persons with matched age,sex, and weight index served as control. Result Fast plasma glucose（FPG） was normal in the both groups. Fast plasma insulin（FPI） was higher（ P ＜0 01） and ISI is lower（ P ＜0 01） in EH group. After 8 weeks treatment, FPI was decreased significantly（ P ＜0 05）, while ISI was greatly improved（ P ＜0 05）. conclusion Serum insulin was higher in hypertensive than healthy persons. Ramipril could decreased BP as well as hyperinsulinism.