Abstract: Aim Angiotensin（1～7）has been shown to inhibit the proliferation of smooth vascular cells, while the effect of whom on SHR glomerular mesangial cell（GMC） and opossum kidney cells（OK） are not clear.\ We determined to study the effect of Ang（1～7）on these two kind of cells. Methods The proliferation of cultured glomerular cells and OK cells were detected by measuring 3H thymidine incorporation. Results The synthesis of DNA in cultured glomerular mesangial cells of SHR and opossum kidney cells were stimulated by Ang Ⅱ in the range of 10 -5 ～10 -6 mol/L, however the effect was blunted when the concentration reached 10 -5 moL.\ Ang（1～7） in the range of 10 -10 ～10 -6 mol/L dose\|dependently inhibited the proliferative effect induced by Ang Ⅱ（10 -6 mol/L） in GMC and OK.\ Benazeprilat, a metabolic product of benazepril, demonstrated a potential antagonist effect on the proliferation of GMC and OK cells by AngⅡ. Conclusion （1）Ang Ⅱ stimulated the growth of cultured glomerular mesangial cells of spontaneously hypertensive rats and opossum kidney cells; （2）Ang（1～7） and benazeprilat inhibite the proliferation induced by angiotensin Ⅱ in cultured glomerular mesangial cells of SHR and OK cells.\ Angiotensin（1～7） and Benazeprilat may have renal protective effect.