Abstract: Objective To study the effect of atorvastatin on intima-media thickness（ITM）of the common carotid artery and coagulative system in hyperlipidemic patierts. Methods Thirty five hyperlipidemic patients were received atorvastatin 10 mg qd for 12 weeks. TC,TG,LDL-C,HDL-C,IMT,fibrinogen（FIB）,thrombin time （TT）,activated partial thromboplastin time（APTT） and prothrombin time （PT） were determind in hyperlipidemic group before and after treatment. The intima-media thickness of carotid artery was measured using echography. Thirty-five normol lipidemic subjects serued as control. Results TC,TG,LDL-C,IMT,FIB were decreased significantly（ P＜ 0.01）in hyper-lipidemic group after 12 weeks. HDL-C,PT TT,APTT were increased significantly （ P＜ 0.05）. Compared with normal lipidemic group,TC,TG,LDL-C,HDL-C,IMT,FIB and PT were not significantly different（ P＞ 0.05）,while TT,APTT were significantly increased （ P＜ 0.05）. Conclusion Atorvastatin treatment not only regresses the structural changes in IMT of the common carotid artery but also improve disorder of coagulation system in hyperlipidemic patients.