Abstract: Obeject To identify the microsatellite DNA polymorphism of adrenomedullin（ADM） gene in patients with essential hypertension（EH） and healthy normotensive subjects. Methods With polymerase chian reactiona（PCR）,ADM genotyping was carried out on 70 normotensive subjects and 90 essential hypertensives without cardio-cerebrovascular diseases. Using radioimmunoassay,plasma ADM concentration was measured. Results The genotype distribution of ADM between the health controls and EH groups was significantly different. The frequencies of 19 alleles in EH groups were higher than the health controls（9.8% vs 3.0%）. However,plasma ADM concentrations were not significantly different among the genotypes. Conclusion Microsatellite DNA polymorphism of adrenomedullin gene may be associated with the genetic predisposition to EH.