Abstract: Objective To investigate whether the insertion/deletion （I/D） polymorphism of the angiotensin converting enzyme （ACE） gene and the A/B polymorphism of the chymase （CMA） gene was associated with left ventricular hypertrophy （LVH） in Chinese essential hypertension. Methods 1042 patients with essential hypertension were studied. The DNA fragments of ACE gene and CMA gene were amplified by PCR and analysed by RFLP. LVDd,IVST and LVPWT were measured by Ultrasonic Cardiogram （UCG）. Results ①The frequencies of the ACE genotypes and I,D alleles were not significantly different between patients with LVH and NLVH. ②The frequencies of the CMA genotypes and A,B alleles were not different between patients with LVH and NLVH. ③No significant differences of age,BMI,pulse,SBP,DBP,LVDd,IVST,LVPWT and LVMI were found in the different genotype groups. ④The genotypes of the ACE and CMA were not related with LVH. ⑤No interaction between the genotypes of the ACE and the genotypes of the CMA. Conclusion No evidences are found to support the association between ACE genotype as well as CMA genotype and the LVH in essential hypertension.