Abstract: Objective This study aims to investigate whether the change of ventricular Ang Ⅱ and BNP levels is involved in the reverse effect of perindopril and carvedilol on ventricular hypertrophy. Methods Twenty 15 week-old male SHRs were divided into three groups: perindopril group （ n =6,8 mg/kg·d -1 ）,carvedilol group （ n =7,4 mg/kg·d -1 ） and sham group （ n =7）. In each group drugs or equal volume of distill water were administered respectively for 6 weeks by gavage. We also used eight age matched WKY as a control group. We measured angiotensin Ⅱ （Ang Ⅱ） and B type natriuretic peptide（BNP） level in rat left ventricular and plasma by high performance liquid chromatography-radioimmunoassay technique （HPLC-RIA） and radioimmunoassay assay（RIA）. Results （1）Perindopril and carvedilol decrease the blood pressure and LV/BW ratio after six weeks treatment （ P ＜0.05）;（2） Perindopril significantly decrease the ventricular Ang Ⅱ level （ P ＜0.05）,but markely increased plasma Ang Ⅱ level （ P ＜0.05）;（3） Carvedilol significantly decrease plasma and ventricular Ang Ⅱ level （ P ＜0.05）;（4） Both perindopril and carvedilol decrease ventricular and plasma BNP level （ P ＜0.05）. Conclusion Perindopril and carvedilol reverse left ventricular hypertrophy which was in associated to the decreases in ventricular Ang Ⅱ level;BNP level might serve as a therapeutic index for reversal of ventricular hypertrophy.