Abstract: ObjectiveTo study the relation between carotid atherosclerosis and serum uric acid and the renal function in patients with essential hypertension.MethodsOne hundred fifty one hospitalized patients male 81 casees, female 70 casees; mean age （72.3±9.5）year were enrolled and their medical records were analysed retrospectively.Based on the presence of carotid plaque, patients were divided into plaque group（group P, n=105） and without plaque group（group N, n=46）.24 hour BP, echocardiography, blood lipids, uric acid, BUN, creatinine and blood sugar were determined and compared between them.ResultsUric acid was significantly higher in group P than in group N （374.6±122.8 vs 317.5±93.0）μmol/L, P＜0.002.Serum creatinine was higher as well （117.7±89.2 vs 95.7±19.7） μmol/L, P=0.017 .Linear regression showed uric acid was weakly correlated to the occurrence rate of plague（r=0.225, P=0.005）.Multiple variables regression analysis indicated that uric acid and age are the 2 determinants for the presence of carotid plaque.ConclusionHigh blood uric acid concentration was associated with carotid plaque.Uric acid and age are the two determinants for the presence of carotid plaque.