Abstract: Objective This study is to investigate the effects of activation of peroxisome proliferator-activated receptor（PPAR）γ on the metabolism and blood pressure in hypertensive rat model with insulin resistance by feeding high fat diet. Methods Thirty male SD rats were randomly allocated into 3 groups. Normal control groups were fed with conventional diet, the model rats were given high fat diet. Medication rats were given insulin sensitizer pioglitazone p.o after high fat for 9 weeks. After 14 weeks BP were measured and then were sacrificed. Blood glucose, insulin level, TNFα, and free fatty acid were measured. Results After 14 weeks plasma insulin level, blood glucose, blood pressure of rats in model group were significantly increased. As compared with untreated models, the level of FFA （367.3±38.1 vs 587.3 ± 35.8）μmol/L,P＜0.05 ,TNFα （10.6±4.2 vs 24.3±8.8）pg/L,P＜0.01 , serum glucose （8.2 ±1.3 vs 9.9±1.8）mmol/L,P＜0.05 ,serum insulin （30.2±5.2 vs 46.1±17.0）mU/L,P＜0.05 ,blood pressure （142.7 ± 15.3 vs 165.4 ± 15.1）mm Hg,P＜0.05 in treatment group were improved, as well as the insulin sensitivity index (4.3±1.0 vs 2.5±0.8,P＜0.01 . Conclusion Insulin resisitance induced by high fat diet may lead to hypertension; activation of PPARγ can attenuates insulin resistance and decreases high blood pressure.