Abstract: Objective To study the effects of amlodipine on renal damage in diabetic rats.Methods Diabetic rat model was established by feeding high-glucose,high-lipid for 6 weeks,and intraperitioneal injection of single dose streptozotocin （STZ;30 mg/kg）.SD rats were randomized to normal control （control group,n=6）,diabetic without treatment（n=6） or with amlodipine treatment（1 mg/kg·d,n=6）for 12 weeks.The renal pathological changes were determined by microscopy;and cellular apoptosis by flow cytometry.The creatinine clearance （Ccr） and urine albumine excretion （Uaer） were determined before and after treatment.Results Amlodpine attenuated the increased extracellular matrix in glomerulus,renal tubules morphological disorder and swollen epithelial cells or vacuolar degeneration in diabetes rats.Amlodipine reduced apoptosis rate of renal cells （apoptosis rate:control group 13.8%±1.3% vs diabetes group 26.5%±2.7% vs amlodipine group 20.0%±2.0%,P＜0.05）,increased Ccr:（control group 0.110±0.020 vs diabetes group 0.021±0.001 vs amlodipine group 0.065±0.004 mL/min,P ＜0.05）,and decreased Uaer:（control group 0.081±0.001 vs diabetes group 0.150±0.004 vs amlodipine group 0.07±0.01 mg/24 h,P＜0.05）.Conclusion Amlodipine protects kidney manifested by reduction of pathologic renal tubule disorder,decreases in renal apoptosis,increases in Ccr,and decreases in Uaer in diabetic rats.