Abstract: Objective To investigate the relationship between central blood pressure and the severity of coro- nary artery disease.Methods Consecutive 204 patients with coronary artery disease were enrolled.All patients were echocardiographically confirmed ejection fraction＞50%.The patients were categorized into as:one-,two-, and three-vessels coronary artery disease group.Central aortic SBP and DBP was measured by cathetarization dur- ing angiography of coronary artery and brachial blood pressure was measured using cuff method.Results Periph- eral SBP,PP and ascending aortic SBP,PP,fractional systolic pressure（FSP=SBP/MAP）were increased and as cending aortic fractional diastolic pressure（FDP=DBP/MAP）was reduced when the diseased coronary vessels were increased（P＜0.05）.Multivariable logistic analysis showed:Age,diabetes mellitus,increased ascending aortic PP,FSP,and reduced FDP were prediposed risk factors for three-vessel coronary artery disease（FSP per increase 0.1,OR=1.142,95%CI=1.032-1.452;PP per increase 10 mmHg,OR=1.195,95%CI=1.151-1.237;FDP per decrease 0.1,OR=0.933,95% CI=0.903-0.975）,（P all＜0.01）.Conclusion Age,diabetes mellitus, increased ascending aortic PP,FSP,and reduced FDP which become a predispose risk factors for three-vessel coro- nary artery disease.