回声追踪技术发现高血压患者早期的颈动脉弹性变化

Early Detection of Carotid Decreased Elasticity by Echo-Tracking Technology in Essential Hypertension Patients

  • 摘要: 目的探讨回声追踪技术(Echo-Tracking)检测原发高血压患者颈动脉弹性的应用价值。方法根据颈动脉超声的检查结果,把原发高血压(EH)患者82例分为两组:颈动脉异常组(EH+颈动脉有斑块,n=43),患者有一侧或双侧颈动脉内中膜增厚和(或)斑块存在;颈动脉正常组(EH+颈动脉无斑块组,n=39),双侧颈动脉内膜中膜无增厚且无斑块存在。另选正常人作为健康对照组(健康组)50例。用回声追踪技术自动跟踪颈总动脉壁的运动,并检测以下参数:收缩期颈总动脉管径(Ds)、舒张期颈总动脉管径(Dd)、压力—应变弹性系数(Eρ)、硬化参数(β)、顺应性(AC)、脉搏波传导速度(PWVβ)和增大指数(AI)。结果 EH+颈动脉有斑块组和 EH+颈动脉无斑块患者组的 Eρ(EH+颈动脉有斑块组:219.2±60.5,EH+颈动脉无斑块组:140.6±51.5比健康组:90.5±23.9,P<0.01)、β(EH+颈动脉有斑块组:16.1±7.8,EH+颈动脉无斑块:13.1±4.0比健康组:8.3±3.0,P<0.01)、PWVβ(EH+颈动脉有斑块组:8.38±1.13,EH+颈动脉无斑块组:7.14±0.92比健康组:5.94±0.65,P<0.05)、AI(EH+颈动脉有斑块组:19.07±9.97,EH+颈动脉无斑块:18.86±6.83比健康组:12.45±4.59,P<0.01)都较健康组显著增加,AC(EH+颈动脉有斑块组:0.70±0.17,EH+颈动脉无斑块组:0.74±0.26比健康组:0.88±0.22,P<0.05)较健康组显著减低,Ds(EH+颈动脉有斑块组:7.94±1.35,EH+颈动脉无斑块组:8.02±1.28比健康组:7.50±1.20,P<0.05)和 Dd(EH+颈动脉有斑块组:7.63±1.19,EH+颈动脉无斑块:7.60±1.22比健康组:7.01±1.01,P<0.05)显著增宽。结论 EH 患者在颈动脉出现内膜中膜增厚或斑块之前,动脉弹性已经发生了变化。回声追踪技术可用来检查动脉硬化早期的动脉弹性改变。

     

    Abstract: Objective To evaluate E-Tracking technology in detecting early elasticity changes in the carotid ar- tery in essential hypertension(EH)patients.Methods Eighty-two cases of EH patients were categorized accord- ing to the finding of B-mode ultrasonography of carotid artery:abnormal carotid group(n=43)with intima-media thickning and/or with plaques in one or both sides;normal carotid group(n=39);normal healthy subjects(n=50) were selected as controls.Echo-Tracking(E-T)technology was performed to follow the movement tracks of the common carotid arterial wall.Systolic diameter of common carotid artery(Ds),diastolic diameter of common carot- id artery(Dd),pressure-strain elastic modulus(Eρ),stiffness parameter(β),arterial compliance(AC),pulse wave conducting velocity(PWVβ)and augment index(AI)were determined by echo-tracking examination.Results The parameters showing in decreased elasticity of artery,Ep(abnormal carotid:219.2±60.5,normal carotid:140.6± 51.5 vs control:90.5±23.9,P<0.01),β(abnormal carotid:16.1±7.8,normal carotid:13.1±4.0 vs control: 8.3±3.0,P<0.01),PWVβ(abnormal carotid:8.38±1.13,normal carotid:7.14±0.92 vs control:5.94±0.65, P<0.05),AI(abnormal carotid:19.07±9.97,normal carotid:18.86±6.83 vs control:12.45±4.59,P<0.01) were all increased,while dimension of carotid artery,as Ds(abnormal carotid:7.94±1.35,normal carotid:8.02± 1.28 vs control:7.50±1.20,P<0.05)and Dd(abnormal carotid:7.63±1.19,normal carotid:7.60±1.22 vs control:7.01±1.01,P<0.05)were increased concomitantly associated with lower AC(abnormal carotid:0.70± 0.17,normal carotid:0.74±0.26 vs control:0.88±0.22,P<0.05).Conclusion The elasticity of the carotid artery in EH was changed before the occurrence of intima-media thickning or plaques.The Echo-Tracking technol- ogy can be used to detect the early elasticity changes of arteriosclerosis.

     

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