Abstract: Objective To study the effect of Angiotensin（1—7）Ang（1—7） on the expression of monocyte chemotractive protein-1（MCP-1）induced by oxidized LDL（ox-LDL）in cultured human umbilical vein endothelial cells（HUVEC）.Methods Original cultured HUVEC were incubated for 24 hours with different concentrations of Ang（1—7）,ox-LDL and A-779 a specific inhibitor of Ang（1—7）alone or combination,respectively.The final concentrations of Ang（1—7）were 10,100 and 1000 nmol/L,and ox-LDL were 25,50 and 100 ng protein/L,re- spectively.The final concentration of A-779 an Ang（1—7）receptor antagonist was 100 nmol/L.MCP-1 anti- gen in the medium was determined by ELISA and its mRNA levels were determined by RT-PCR.Results Ox-LDL （on the range of 25—100 mg protein/L）dose-dependently increased MCP-1 release and up-regulated MCP-1 gene transcription（P＜0.05-0.01）.Ang（1-7）did not affect the expression of MCP-1 at basal condition（P＞0.05） but inhibited the protein and gene expression of MCP-1 in a dose-dependent manner on the range of 10-1000 mmol/L（P＜ 0.05-0.01）.The effects of Ang（1—7）was prevented by A-779.Conclusion Angiotensin（1—7）effectively in- hibits the expression of monoeyte chemotractive protein-1 induced by oxidized LDL in HUVEC via its specific receptor.