压力负荷型心脏肥大大鼠心电图

Characteristics of Electrocardiography in Pressure Overload-induced Cardiac Hypertrophy Rats

  • 摘要: 目的采集压力负荷型心脏肥大大鼠心电图检测数据并分析其特点。方法常规腹主动脉缩窄法建立大鼠压力负荷型心脏肥大模型,超声心动图、心脏称量评定心脏肥大建模成功。标准化心电图测量各肢体及胸导联并统计分析数据。结果造模2周后超声心动图检测示心脏肥大组的左室后壁舒张末期厚度、室间隔舒张末期厚度、左室舒张末期内径均大于对照组,证实造成心脏肥大。心电图检测显示几个特点:心脏肥大组:1)心电轴较假手术对照组偏左;2)VA、VB、VC 导联 R 波振幅均明显大于对照组(P<0.01);3)心脏肥大组 VA、VB、VC 导联绝大多数"J"点抬高明显,较对照组差异有非常显著意义(P<0.01)。结论压力负荷型心脏肥大大鼠心电图具有明显特征,心电图检查能作为无创性评价大鼠心脏肥大的有效方法。

     

    Abstract: Objective To analyze the electrocardiography(ECG)data of pressure overload-induced cardiac hy pertrophy rats.Methods Pressure overload cardiac hypertrophy was induced by abdominal aorta constriction. Echocardiogram and heart weight measurement demonstrated the occurrence of cardiac hypertrophy.Standardized ECG parameters of limb and chest were measured and statistically analyzed.Results Two weeks after hypertrophy models were established,echocardiogram showed greater LVPWTd,IVSTd,LVDd.ECG showed that left axis deviation and higher R waves in VA,VB,VC(P<0.01),with significant and ubiquitous J point elevation in VA, VB,VC(P<0.01).Conclusion ECG in pressure overload-induced cardiac hypertrophy rats exhibits obviously characteristic features ECG which can be used as one of adjunctive effective and noninvasive methods to evaluate the cardi- ac hypertrophy of rats.

     

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