肥胖男性患者血浆8异前列腺素F2α与细胞黏附分子的关系

The Levels of 8-iso-prostaglandin F2α and Cell Adhesion Molecules in Male Obesity

    摘要
  • 摘要: 目的探讨男性单纯肥胖患者血浆8异前列腺素 F2α水平与细胞黏附分子的关系。方法测定36例男性肥胖患者和30例健康非肥胖男性个体的血8异前列腺素 F2α(8-iso-PGF2α),可溶性细胞间黏附分子1（sICAM-1）和 E 选择索。结果肥胖患者体质量指数（BMI）、腰围/臀围（WHR）、空腹胰岛素、胰岛素抵抗指数（HOMA-IR）、血浆8-iso-PGF2α、sICAM-1和E选择素均显著高于正常个体（P<0.05或 P<0.01）。男性肥胖组相关分析:8-iso-PGF2α与 BMI、E 选择素和 HOMA-IR 呈正相关（相关系数分别为0.28,0.33,0.31,P<0.05）。多元逐步回归分析:校正年龄和 BMI 后,偏相关分析显示,血浆8-iso-PGF2α仍与 E 选择素呈正相关（r=0.265,P<0.05）。结论血浆8-iso-PGF2α可能是男性单纯肥胖患者发生细胞黏附分子变化的重要因素之一。

     

    Abstract: Objective To investigate the relationship between the levels of 8-iso-prostaglandinF2α(8-iso- PGF2α)and in obese men.Methods The levels of soluble intercellular adhesion molecule-1（sICAM-1）,E-selectin and 8 iso-PGF2αwere measured in obese men and compared to normal controls.Results The body mass index （BMI）,waist hip ratio（WHR）,fast plasma insulin,homeostasis model assessment（HOMA IR）,and levels of 8- iso-PGF2α,sICAM-1 and E-selectin were significantly higher in obese men than that in normal controls（P＜0.05）. There was a significantly positive correlation between the level of 8-iso-PGF2αand BMI,E-selectin and HOMA-IR in obese men（r:0.28,0.33,0.31,all P＜0.05）.After adjustment for age and BMI,apartial correlation analysis show that 8-iso-PGF2αconcentration in obese men was correlated with E-seleetin（r=0.265,P＜0.05）.Conclusion The levels of 8-iso-PGF2αmight play importment role in change of CAMs in obese men.

     

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