正常高值血压患者血清脂质过氧化水平变化及其意义

Serum Lipid Peroxidation Levels in Patients with Pre-hypertension

    摘要
  • 摘要: 目的观察正常高值血压(PH)患者血清脂质过氧化水平的变化,探讨其在高血压治疗和预防方面的意义。方法按照JNC7诊断标准筛选出PH患者106例,原发性高血压(EH)患者91例,同时随机挑选血压正常健康人(NT)98例作为对照。采用生化法测定血清中超氧化物歧化酶(SOD),谷胱甘肽过氧化物酶(GSH-PX),丙二醛(MDA),过氧化脂质(LPO)的含量。结果PH组患者血中总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)及体质量指数(BMI)明显高于NT组(P<0.05或0.01)。PH组和EH组血清MDA、LPO明显高于NT组MDA,PH组(13.8±2.2),EH组(18.9±2.0)比NT组(10.5±1.3)μmol/L,分别为P<0.05和P<0.01;LPO,PH组(2.4±0.4),EH组(2.8±0.4)比NT组(1.9±0.2)μmol/L,分别为P<0.05和P<0.01。PH组血清GSH-PX明显高于NT组,EH组却明显低于NT组GSH-PX,PH组(0.22±0.04)比NT组(0.20±0.03)μmol/L,P<0.05;EH组(0.18±0.04)比NT组(0.20±0.03)μmol/L,P<0.05。PH组和EH组血清SOD都较NT组低SOD,PH组:(72.4±10.7)、EH组:(65.1±10.0)比NT组(79.0±10.2)U/mL,分别为P<0.05和P<0.01;多因素logistic回归分析,正常高值血压与BMI、GSH-PX、MDA、LPO呈正相关(β为0.496、1.768、1.565、1.204;分别为P<0.05、P<0.05、P<0.01、P<0.01)。正常高值血压与SOD呈负相关(β为-0.115,P<0.05)。结论正常高值血压患者血清SOD下降、GSH-PX上升、MDA、LPO等过氧化产物增高,提示正常高值血压患者体内氧化应激增强。

     

    Abstract: Objective To study oxidative stress in prehypertensive（PH） patients. Methods One hundred and six PH patients and 91 essential hypertensive（EH） patients by JNC 7 were recruited,98 normotensive（NT） subjects were served as controls. The levels of superoxide dismutase（SOD）,glutathione peroxidase（GSH-PX）,malonyldialdehyde（MDA）and lipid oxide（LPO） were determined by biochemistry. Results Serum Lipids （TC,TG,LDL-C） and body mass index （BMI） were significantly higher in PH and EH compared to NT. MDA,LPO were significantly increased in group PH and EH compared to NTMDA,PH group（13.8±2.2）,EH group（18.9±2.0）vs NT group （10.5±1.3）μmol/L,respectively,P＜0.05 and P＜0.01; LPO,PH group（ 2.4±0.4）,EH group（2.8±0.4） vs NT group（1.9±0.2）μmol/L,respectively,P＜0.05 and P＜0.01. However,GSH-PX was increased in PH while decreased in EHGSH-PX,PH group:（0.22±0.04）vs NT group:（0.20±0.03）μmol/L,P＜0.05; EH group:（0.18±0.04） vs NT group:（0.20±0.03）μmol/L,P＜0.05. SOD was significantly decreased in PH and EH in related to NTSOD,PH group:（72.4±10.7）,EH group:（65.1±10.0） vs NT group:（79.0±10.2）U/mL,respectively,P＜0.05 and P＜0.01. Multivariate analysis showed BMI,SOD,GSH-PX,MDA,LPO were predisposing risk factors for prehypertension（β=0.496,-0.115,1.768,1.565,1.204; respectively,P＜0.05,P＜0.05,P＜0.05,P＜0.01,P＜0.01）. Conclusion Oxidative stress are enhanced in prehypertensive patients.

     

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