Abstract: Background Calcium channels exist in both smooth muscle cells and bone cells. Do calcium channel blockers （CCB） affect the metabolism of calcium in bone cells while they act on the smooth muscle cells? Objective To observe the effects of different CCB on bone mineral density （BMD） and fracture ratio in the elderly patients with hypertension. Methods Six hundred and fifty elderly hypertensive patients aged 60 to 81 were enrolled,all of whom had taken CCB for more than 3 years except the ones in control group. The patients were divided into nifedipine group （30 mg qd,n=175）,felodipine group （5 mg qd,n=182） and amlodipine group （5 mg qd,n=198） according to their different CCB treatment. The others,without CCB,were served as control group （n=95）. Compared respectively the difference of BMD,fracture ratio,concentration of calcium,alkaline phosphatase and phosphorus in the serum between every treatment group and the control group. Results There was no significant difference in BMD between the treatment groups and the control group nifedipine group（1.12±0.14） vs felodipine group （1.09±0.16） vs amlodipine group （1.13±0.15） vs control group （1.11±0.15）g/cm2,P＞0.05. There was no significant difference in fracture ratio （P＞0.05） among nifedipine （9.1%）,felodipine（9.3%）,amlodipine （8.6%） and control groups （10.5%）. Similarly,there was no difference in the serum level of calcium,alkaline phosphatase and phosphorus between treatment groups and control groups （P＞0.05）. Conclusion Taking nifedipine or felodiine or amlodipine with therapy dose in a long term will not significantly increase the morbidity of osteoporosis and fracture,and will not disturb the calcium metabolism in elderly patients with hypertension.