Abstract: Objective To study the effect of bisoprolol on change of heart rate turbulence（HRT） in essential hypertension patients with different types of left ventricular remodeling.Methods Two hundred and forty-two patients with essential hypertension were divided into normal（NG） group（n=59）,concentric remodeling（CCR） group（n=58）,concentric hypertrophy（CCH） group（n=61） and eccentric hypertrophy（ECH） group（n=64） according to the pattern of the left ventricular remodeling by using echocardiography.Each group was randomly subdivided into conventional treatment group or bisoprolol treatment group.The numbers of ventricular premature beats were calculated before and after four weeks treatment by 24 h dynamic electrocardiography.Turbulence onset（TO） and turbulence slope（TS） of the each groups were calculated.Results TO were declined in a graded manner from ECH to CCR in ECH（0.58±0.63）% ＞CCH（0.39±0.38）% ＞CCR（0.19±0.32）%,P＜0.01,while TS were correspondingly increased in ECH（2.54±1.13） ＜CCH（5.12±1.26） ＜CCR（14.21±0.46）ms/RR,P＜0.01.No significant difference of TO and TS between NG and CCR.Four weeks both bisoprolol and conventional treatment significantly decreased TO and increased TS. Covariance analysis revealed that the impact of bisoprolol on TO and TS were more significant in CCH and ECH patients than that by conventional treatment,with little effect on NG and CCR patients.Conclusion Heart rate turbulence was related to the features of left ventricular remodeling in patients with essential hypertension.The more serious left ventricular remodeling,the more pronounced abnormality in HRT was found.Bisoprolol improve the irregularity of heart rate turbulence in CCH and ECH patients but not in NG and CCR patients.