原发性高血压患者白蛋白尿与糖代谢紊乱

Relationship Between Albuminuria and Dysglycaemia in Patients with Essential Hypertension

  • 摘要: 目的分析我国不同区域原发性高血压患者的白蛋白尿与血压及糖代谢紊乱的关系。方法在我国5个城市随机抽取诊断明确的无糖尿病的原发性高血压患者5021例,其中男性2492例占49.6%,女性2529例占50.4%,年龄(62.2±12.0)岁。所有研究对象进行尿常规及尿白蛋白/肌酐比值的检测,对空腹血糖≥5.6mmol/L的高血压患者进行简化的口服糖耐量试验。2次检查尿白蛋白/肌酐异常或尿常规中蛋白≥0.3g/L并除外尿中存在白细胞、红细胞的患者,定义为尿白蛋白阳性。根据血压水平将患者分为血压控制良好组(血压<140/90mmHg,n=2236)和血压控制不良组(血压≥140/90mmHg,n=2785)。根据糖代谢情况将患者分为糖代谢正常组(n=3600)、糖调节异常组空腹血糖≥5.6且<7.0mmol/L和(或)服糖水后2h血糖≥7.8且<11.1mmol/L,n=1067和糖尿病组空腹血糖≥7.0mmol/L和(或)服糖水后2h血糖≥11.1mmol/L,n=354,对血压、血糖水平与患者白蛋白尿的检出进行统计分析。结果①原发性高血压患者白蛋白尿的总检出率为28.8%,随血压水平上升,尿白蛋白的排出增高。②高血压患者糖代谢异常检出率为28.3%。白蛋白尿异常检出率在正常血糖组为26.3%,糖调节异常组为32.6%,糖尿病组为42.3%。③与血压控制良好组相比,血压控制不良组合并糖尿病更多(5.8%比8.1%,P=0.006)。④血糖控制不良的高血压患者有更多的靶器官损害或心脑血管事件发生(46.0%比37.3%)。结论原发性高血压患者血压控制不良以及糖代谢异常是白蛋白尿发生的重要因素。

     

    Abstract: Objective To investigate the relationship between albuminuria,blood pressure and dysglycaemia in patients with essential hypertension in China’s five regions. Methods Fifty hundred twenty-one patients with clearly diagnosed essential hypertension and without diabetes were enrolled in. The mean age of participants was (62.2±12.0) years old. Among them,2492 were male (49.6%) and the other 2529 were female (50.4%). The urine routine examination was performed,creatinine concentration was measured and the urine albumin/creatinine ratio was calculated in all these patients. Twice abnormal albumin/creatinine ratio or urine protein more than 0.3 g/L and no WBC or RBC in urine routine examination was defined as positive albuminuria. In patients with fasting blood glucose more than 5.6 mmol/L,simple oral glucose tolerance test (only 2 hours glucose level after drinking 75 g-glucose-water was measured) were performed. The association of albuminuria,blood pressure level and dysglycaemia were analyzed. According to the blood pressure level,patients were divided into controlled group(blood pressure <140/90 mm Hg,n=2236) and uncontrolled group (blood pressure ≥140/90 mm Hg,n=2785). According to the glucose level,patients were divided into normal glucose group (n=3600),impaired glucose regulation group (fasting glucose ≥5.6 and <7.0 mmol/L and (or) oral glucose tolerance test 2 hour glucose ≥7.8 and <11.1 mmol/L,n=1067) and diabetes group (fasting glucose ≥7.0 mmol/L or oral glucose tolerance test 2 hour glucose ≥11.1 mmol/L,n=354) respectively. Results ①The total albuminuria detection rate was 28.8%,which was increased with the increasing of blood pressure. ②28.3% patients complicated with dysglycaemia. The higher the blood glucose level,the more the urine protein excretion (normal glucose group 26.3%,impaired glucose regulation group 32.6%,diabetes group 42.3%). ③Compared with controlled blood pressure group,more patients complicated with diabetes in uncontrolled blood pressure group(5.8% vs 8.1%,P=0.006). ④Patients with dysglycaemia had more heart,cerebral and renal events(46.0% vs 37.3%). Conclusion Uncontrolled blood pressure and dysglycaemia were important risk factors of albuminuria in patients with essential hypertension.

     

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