Abstract: Objective To investigate the impacts of hypertension,lipid disorders,and hyperglycemia on major diabetic complications,cardiovascular diseases （CVD）,kidney diseases （DKD） and retinopathy （DR）. Methods A total of 9258 diabetic patients male 5058,female 4200,age （55.1±11.7）years,diabetes duration 1-480 months,BMI （25.8±3.4）kg/m2 were divided into groups based on their blood pressure levels （every 20 mm Hg increase of SBP from 90 to 230 mm Hg and every 10 mm Hg increase of DBP from 60 to 120 mm Hg ）. Patients were also grouped based on quartiles of their blood lipids and glucose levels. Cardiovascular diseases,kidney diseases and diabetic retinopathy were compared and analyzed. CVD,DKD and DR were chosen as dependent variables respectively; age,disease durations,BMI,SBP,DBP,cholesterol （TC）,triglycerides （TG）,LDL-C,HDL-C,and HbA1c as independent variables. Multiple regression analysis was used for data analysis. Results Blood pressure increased significantly with aging and longer duration of diabetes. The prevalence of CVD,DKD and DR were significantly higher in these groups with higher SBP or DBP. There was a higher prevalence of CVD in the patients with TC level 5.0-5.72 and ＞5.72 mmol/L than those with TC ＜5.0 mmol/L. When TG＞1.57 mmol/L,the prevalence of CVD and DKD was increased,but no significant difference of DR prevalence was found in patients with different levels of TG. There were higher prevalence of CVD and DKD in patients with LDL-C＞3.01 mmol/L than those with LDL-C ＜3.01 mmol/L. There was a higher prevalence of DR with LDL-C＞3.01 mmol/L than those with the value ＜1.07 mmol/L. The influences of different levels of HDL-C on CVD,DKD and DR were no observed. There were higher prevalence of CVD,DKD and DR in patients with HbA1c≥6.5% than those with HbA1c＜6.5%. Multiple regression analysis showed that BMI,HbA1c,duration of diabetes,TG,SBP and DBP were risk factors for DKD; BMI,HbA1c,SBP and duration risk factors for DR; BMI,HbA1c,age SBP and HDL-C risk factors for CVD. Conclusions Hypertension aggravates the diabetic macro-and micro-vascular complications. The prevalence of CVD,DN,and DR was significantly higher when the patients with HbA1c≥6.5%,TC＞5.72 mmol/L,LDL-C＞3.6 mmol/L.