Abstract:
Objective To study the prevalences of hyperuricemia(HUA)and hypertension in community residents and the association between them,to look for the methods for effective prevention of uric acid associated cardiovascular diseases.Methods A total of 6273 urban community residents,aged 18-75 years old,received cross-sectional investigation in Xiangshan District,Guilin City.Fasting blood glucose and urine samples were collected for evaluating blood glucose level,renal function,and levels of insulin,high-sensitivity C-reactive protein.Questionnairing and physical examination were performed at the same time.Results The prevalence of HUA was 23.5%,28.4% in the males,which was significantly higher than 19.7% in the females(P <0.01).The prevalence of hypertension was 27.8%,37.8% in the hyperuricemia(HUA)residents,which was significantly higher than 24.7% in the residents with normal uric acid level(P <0.01).For all the residents,the relative risk(RR)for hypertension in the hyperuricemia residents was 1.8 times higher than the residents with normal uric acid level.The RR was 3.3 times higher in residents younger than 30 years old,2.1 times higher in residents between 30-60 years old,but not significantly different in residents older than 60 years old.The prevalence of hypertension was significantly higher in the residents with uric acid level over the 50 percentile when compared to those below the 50 percentile,especially the prevalence of elevated systolic blood pressure.After adjusting for serum creatinine,age and gender,the uric acid level was positively related to the levels of systolic blood pressure,diastolic blood pressure and high-sensitivity C-reactive protein(P <0.01).Conclusion In the residents with HUA,the prevalence of hypertension is higher than those with normal uric acid level,especially in the younger residents.The main influence of hyperuricemia on the blood pressure is the increasing the prevalence of elevated systolic blood pressure.The higher prevalence of hypertension in hyperuricemia population is closely associated with micro inflammatory reaction.