H型高血压与急性心肌梗死的相关性

Association between H type hypertension and acute myocardial infarction

  • 摘要: 目的探讨H型高血压与急性心肌梗死(AMI)的关系。方法收集2009-12-2010-06于唐山市工人医院心内科入院的符合入选标准的原发性高血压患者合并冠状动脉粥样性心脏病(冠心病)124例,同型半胱氨酸(Hcy)水平≥10μmolL为H型高血压组(H型组,n=61),Hcy水平<10μmol/L为单纯高血压组(单纯组,n=63);所有患者均行冠脉造影检查,且AMI患者均经冠状动脉造影检查有血管急性闭塞;用酶法测定Hcy水平,比较血清Hcy水平的差异。结果 H型组中AMI患者的血清Hcy水平高于非AMI患者(20.24±9.52)比(13.35±2.15)μmol/L,P<0.01。单纯组中AMI患者的血清Hcy水平低于非AMI患者(7.61±1.29)比(8.89±2.71)μmol/L,P<0.05,且AMI患者的血清总胆固醇水平高于非AMI患者(5.46±0.96)比(4.65±0.75)mmol/L,P<0.05,血清低密度脂蛋白胆固醇水平高于非AMI患者(4.11±0.87)比(2.80±0.67)mmol/L,P<0.05,多元线性逐步回归分析显示,H型高血压是AMI的独立影响因素(OR=4.685,P<0.01)。结论 H型高血压与AMI密切相关,是AMI独立危险因素,并且与血脂无相关性。

     

    Abstract: Objective To investigate the association between H type hypertension and acute myocardial infarction(AMI).Methods We selected 124 inpatients with hypertension and coronary heart disease of Tangshan workers’ hospital from december 2009 to June 2010,among whom 61 patients were classified as H group and the other 63 patients as simple group.According to the plasma hyperhomocysteinemia(Hcy)cutpoint ≥10 or <10 μmol/L.All the patients coronary angiography and AMI patients were confirmed acute vascular occlusion.The differences of the Homocysteine levels were determined by immuoassay.Results The serum Hcy level of the AMI patients in H group was higher than that of non-AMI patients I(20.24±9.52)vs non-AMI(13.35±2.15)μmol/L,P <0.01 ;The serum Hcy level of the AMI patients in simple group was lower than that of non-AMI patients I(7.61±1.29)vs without AMI(8.89±2.71)μmol/L,P <0.05 ;The serum TC level of AMI patients was higher than that of non-AMI I(5.46±0.96)vs non-AMI(4.65±0.75),P <0.05 ;The serum low density lipoprotein cholesterol was higher than that of non-AMI patients I(4.11±0.87)vs non-AMI(2.80±0.67)μmol/L,P <0.05 .Logistic regression analysis showed H type hypertension was risk factor for acute myocardial infarction(OR =4.685,P <0.01 .Conclusion There are a close relation between H type hypertension and acute myocardial infarction,but no relation between H type hypertension and the levels of blood lipid.H type hypertension was risk factor for acute myocardial infarction.

     

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