Abstract:
Objective To investigate the effects of hypertension and metabolic factors such as plasma glucose,lipid,and obesity on the left ventricular hypertrophy in the patients with metabolic syndrome.Methods Fasting plasma glucose(FPG),serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)were detected in 202 patients who visited our hospital from 2006 to 2007.According to whether they suffered hypertension or other metabolic items,the subjects were divided into 9 groups:normal control group(n =21),essential hypertension(n =49),hypertension with hyperglycemia(group A,n =19),hypertension with dyslipidemia(group B,n =16),hypertension with obesity(group C,n =17),hypertension with hyperglycemia and dyslipidemia(group D,n =18),hypertension with hyperglycemia and obesity(group E,n =17),hypertension with dyslipidemia and obesity(group F,n =21),hypertension with hyperglycemia,obesity and dyslipidemia(group G,n =24).Left ventricular end-diastolic diameter(LVEDd),left ventricular posterior wall thickness(LVPWT)and interventricular septal thickness(IVST)were determined by echocardiogram.Left ventricular mass index(LVMI)was calculated based on these parameters.Results Compared with normal control group(72.6±13.8)mm,LVMI was significantly elevated(99.2±22.0)mm of essential hypertension,(108.1±13.4)mm of group A,(119.4±23.6)mm of group B,(127.3±15.0)mm of group C,(134.7±20.8)mm