Abstract: Objective To investigate the prevalence and the characteristics of Metabolic Syndrome（MS） in pre-dialysis chronic renal failure（CRF） patients.Methods From January 2009 to January 2010,298 cases of pre-dialysis CRF inpatients（pre-dialysis CRF group,111 male and 187 female,aged from 30 to 62 years） in our nephrology department were divided into diabetic nephropathy（n=30） and non-diabetic nephropathy subgroup（n=268）.And 300 cases of age-and sex-matched persons accepted heath examination with normal renal function served as the control group.Waist circumference,blood pressure,fasting blood glucose,lipid profile,renal function,electrolytes,24-hour urinary protein and fundus examination were tested for each subject.MS was defined by International Diabetes Federation criteria.The prevalence of MS was compared between the groups.Results The prevalence of MS in pre-dialysis CRF subjects was significantly higher than that in the control participants（21.8% vs 11.3%）.Compared with the controls,the occurrence of hypertension（93.0% vs 35.0%）,hyperuricemia（87.6% vs 20.7%） and hypertriglyceridemia（40.6% vs 25.7%） in pre-dialysis CRF subjects was significantly increased（all P＜0.01）.The incidence of abdominal obesity（66.7% vs 25.4%） and hyperglycemia（100% vs 16.0%） in diabetic nephropathy subgroup was significantly higher than that in non-diabetic nephropathy subgroup（all P＜0.01）.Conclusion The prevalence of MS and hyperuricemia in pre-dialysis CRF patients increased significantly.