Abstract: Objective To investigate the relationship between flow mediated dilation （FMD） and uric acid in essential hypertensive patients with left ventricular hypertrophy （LVH）. Methods Two hundred and seventy-seven outpatients 159 men,118 women; aged （58.5±11.0）years with mild to moderate hypertension from the First Affiliated Hospital of Fujian Medical University were enrolled between August 2006 and February 2011. The patients were divided into two groups according to left ventricular mass index （LVMI）: hypertensive patients with LVH （LVH group, n=83） and without LVH （non-LVH group, n=194）. Forty-one normotensive patients served as control group. LVH was determined by echocardiography. FMD was measured as the percentage change in brachial artery diameter during reactive hyperemia using high-resolution ultrasonography. Uric acid was detected by urease indophenol. Results Compared with control group, in both non-LVH and LVH group the FMD were significantly lower （7.3±3.5）%, （5.7±2.2）% vs （9.9±3.1）%, P＜0.05, the incidence rates of hyperuricemia （HUA） were significantly higher 39.2%, 40.1% vs 17.1%, P＜0.05 respectively. In hypertensive patients, FMD was lower in those with HUA than in without HUA （6.3±2.5）% vs （7.1±3.6）%, P＜0.05. For non-LVH patients, FMD was lower in those with HUA than without HUA （6.5±1.9）% vs （7.7±2.6）%, P＜0.05. For LVH patients, there was no difference in FMD no matter the presence of HUA. correlation analysis showed that FMD was negatively correlated with uric acid （r=-0.18, P＜0.05）. Conclusion Uric acid correlated with the endothelial function, but the correlation was not significant in essential hypertensive patients with LVH.