Abstract: Objective To exam the effects of different drug combinations on the control of hypertension in workplace. Methods Beginning from April, 2009, the active workers with hypertension received comprehensive hypertension treatments. Patients were either underground or supporting workers from Kailuan Group. Anti-hypertension drugs were distributed freely. Patients received one of the following combinations: 1. nitrendipine 5 mg 2/d plus captopril 12.5 mg 2/d, or 2. nitrendipine 5 mg 2/d plus spirolactone 20 mg 1/d, or 3. hydrochlorothiazide 12.5 mg 1/d plus captopril 12.5 mg 2/d or 4. hydrochlorothiazide 12.5 mg 1/d plus spirolactone 20 mg 1/d. Patients also received health education and administrative intervention. During the treatment period, blood pressure were measured every two weeks. Results After treatment, patients obtained significant reduction in both SBP （134.1±13.1） vs （147.6±17.5）mm Hg and DBP （86.6±8.9） vs （96.9±10.9） mm Hg （all P＜0.01）. SBP reduced （14.1±23.3）, （11.4±23.0）, （12.1±21.7） and （14.8±20.9）mm Hg; DBP （9.5±15.5）, （7.4±14.8）, （10.2±14.4） and （12.1±13.6）mm Hg respectively in nitrendipine/captopril, nitrendipine/spirolactone, hydrochlorothiazide/captopril and hydrochlorothiazide/spirolactone group. The degree of BP reduction in hydrochlorothiazide/spirolactone was larger than other groups. The effective rates were 67.0%, 62.9%, 68.5% and 77.3% respectively in nitrendipine/captopril, nitrendipine/spirolactone, hydrochlorothiazide/captopril and hydrochlorothiazide/spirolactone group. The effective rate in hydrochlorothiazide/spirolactone group was higher than other groups （P＜0.01）. Conclusion The hypertension treatments with different drug combinations can effectively reduce blood pressure in the workplace.