Abstract: Objective To investigate the serum level and relevant factors of complement c1q tumor necrosis factor-related protein 1 （CTRP1） in patients with obstructive sleep apnea （OSA） and primary aldosteronism （PA）. Methods A total of 28 hypertensive inpatients with confirmed OSA and PA were selected as case group. A number of 30 essential hypertensive inpatients with OSA hospitalized at the same time were selected as control group. In all subjects, the levels of PRA, angiotensin Ⅱ（Ang Ⅱ） and aldosterone （Ald） were measured by adioimmunodetection, and the levels of serum CTRP1 was determined by enzyme-linked immunosorbent assay. Results The difference of Ald levels between the case group and the control group was of statistical significance （P＜0.05）, while there were no statistic significant differences in the levels of CTRP1, PRA, Ang Ⅱ, C-reaction protein （CRP）, serum potassium and sodium between two groups. Pearson correlation analysis indicated that there was no correlation between CTRP1, Ald, AHI, other factors related to OSA and PA in the whole population, but there was negative correlation between CTRP1 and Ang Ⅱ（r=-0.454, P＜0.05） in patients with OSA and PA. Conclusion There is no difference in the level of CTRP1 between patients with OSA and PA and the essential hypertension patients with OSA. The level of CTRP1 is negatively correlated with Ang Ⅱ but unrelated to aldosterone in patients with OSA and PA.