Abstract: Objective To investigate the effects of antihypertensive treatment on recurrent stroke in patients with stroke/transient ischemic attack （TIA）. Methods The original data of randomized clinical trial research published between Jan. 2000 and Jan. 2009, which focused on the prevention of stroke by lowering blood pressure, were searched in PubMed database, EMbase, Cochrane library, Chinese biomedical literature database, CNKI, VIP, and so on. The qualified data scored on the Downs ＆ Black scale were processed with a meta-analysis. Subgroup analyses were used to compare the data from trials that respectively used diuretics and renin-angiotensin-aldosterone system （RAAS） inhibitors as the mainstay of active treatment. Results Ten randomized controlled studies were eligible for analysis, including 38 227 patients in total. The pooled odds ratio for the prevention of recurrence stroke was 0.78 （95% CI 0.68-0.90, P=0.007）, 0.63 （95% CI 0.54-0.73, P＜0.01） in the studies using diuretics as a major component of experimental therapy, and 0.93 （95% CI 0.87-1.01, P=0.086） in the studies in which the mainstay of treatment consisted of RAAS inhibitions. As compared with the RAAS heterogeneity in the odds ratios among all studies（P＜0.01）. The reduction averaged 5.1/2.5 mm Hg of systolic/diastolic blood pressure in all studies, 8.5/3.6 mm Hg in the diuretics studies, and 4.0/2.1 mm Hg in the RAAS inhibitors studies respectively. A weighted regression analysis showed that it was a significant correlation between the odds of recurrence stroke and the reduction of systolic blood pressure. Conclusion Antihypertensive therapy may reduce the risk of stroke recurrent significantly.