Abstract: Objective To investigate the effects of different antihypertensive agents on plasma brain natriuretic peptide（BNP）and left ventricular mass index（LVMI）in hypertensive patients with left ventricular hypertrophy（LVH）. Methods A total of 224essential hypertensive inpatients and outpatients with LVH from a tertiary A hospital were enrolled and divided into four groups. These subjects were treated by the combination of thiazad with benapril,candesartan,nifedipine CR,or with metroprolol respectively for twelve weeks. Plasma BNP,LVMI and the ratio of mitral flow early diastole（E）to atrial contraction（A）（E/A）were monitored before and after the therapy. The correlation between BNP and LVMI,as well as E/A was analyzed. Results The BNP levels and LVMI were reduced while E/A increased significantly after treatment than those before treatment. BNP and E/A were improved more obviously in combined regimen of thiazad plus candesartan than the other therapeutic schemes,although no statistical significant difference in LVMI was found between the treated groups. BNP levels were positively correlated with LVMI before（r=0.47）and after（r=0.45）the treatment（all P＜0.01）,whereas negatively related to E/A at the initiation（r=-0.41）and the end（r=-0.52）of therapeutic course（all P＜0.05）.Conclusion At the early stage of antihypertensive remedy,angiotensin receptor blocker may have advantages in decreasing plasma BNP levels and ameliorating left ventricular diastolic function.