Abstract: Maladaptive tissue repair after myocardial infarction is the key factor in determining cardiac pump function and prognosis. Although advanced basic research and improved medical management have led to a considerable reduction of patient’s annual mortality rate,the prevalence of chronic heart failure after re-establishment of coronary blood supply is still high. Therefore,illustration of cellular and molecular mechanisms of cardiac repair and development of specific interventions remain an active area of investigation.Based on the characteristics of tissue repair at different stages after myocardial infarction,this review will briefly discuss the therapeutic advancements in limiting myocardial infarction and repair,including anti-infarction therapy,re-construction of extracellular matrix by injecting biomaterials,in vitro-engineered myocardial tissue and approaches of stem cell delivery to the damaged heart.