心外膜脂肪体积与血压水平及血压昼夜节律变化的关系

Epicardial adipose tissue volume in relation to levels and circadian rhythms of blood pressure

  • 摘要: 目的通过运用双源CT(DSCT)心脏成像测定心外膜脂肪体积(EATV),探讨EATV与血压水平和血压昼夜节律变化的关系。方法采集接受DSCT心脏冠状动脉造影的301例患者的资料,通过DSCT测量心脏EATV总量。301例患者中91例高血压患者住院期间接受了动态血压监测。以EATV四分位数将91例患者分组后观察各组患者24h动态血压监测指标的差异。多因素Logistic回归分析EATV与高血压的关系。结果高血压组EATV高于非高血压组(103.85±41.32)比(92.35±41.59)cm3,P<0.05,在排除肥胖、糖尿病等高血压的危险因素后EATV仍是影响高血压发生的独立因素(P<0.05)。非杓型和反杓型高血压患者的EATV高于杓型高血压患者(108.26±31.06)、(119.83±28.45)比(99.26±29.45)cm3,均P<0.05。按照EATV四分位数分组后,4组患者24h平均收缩压、24h平均舒张压、白天平均收缩压、白天平均舒张压、夜间平均收缩压及夜间平均舒张压等参数随EATV增加逐步递增,组间差异有统计学意义(均P<0.01)。结论 EATV增加与高血压发生、血压昼夜节律紊乱密切相关。

     

    Abstract: Objective To investigate the relation of epicardial adipose tissue volume(EATV),determined by dualsource CT(DSCT)cardiac imaging,to levels and circadian rhythms of blood pressure. Methods The data of 301 subjects receiving DSCT coronary angiography were collected,while EATV of each subject was measured by DSCT. Of the 301subjects,91with hypertension received ambulatory blood pressure monitoring(ABPM)during their stay at the hospital. Meanwhile,91patients with hypertension were divided into four groups according to quartiles of EATV,and different 24-hour ABPM parameters of the four groups were observed. Multivariate logistic regression analysis was used to study the correlation between EATV and hypertension. Results EATV of the hypertension group was significantly higher than that of the non-hypertension group(103.85±41.32)vs(92.35±41.59)cm3,P <0.05. After excluding obesity,diabetes and other cardiovascular risk factors,EATV still was an independent risk factor for hypertension(P<0.05);The EATVs of the non-dipper hypertension group and reverse dipper hypertension group were significantly higher than that of the dipper hypertension group among patients receiving dynamic electrocardiogram examination(108.26±31.06),(119.83±28.45)vs(99.26±29.45)cm3,both P<0.05. Mean 24-hour systolic blood pressure(24hSBP),mean 24-hour diastolic blood pressure(24hDBP),mean daytime SBP(dSBP),mean daytime DBP(dDBP),mean nighttime SBP(nSBP),mean nighttime DBP(nDBP)and other parameters of the four groups,divided in accordance with quartiles of EATV,progressively increased with the increase of EATV(all P<0.01). Conclusion Increasing EATV is associated with the occurrence of hypertension,and it can aggravate abnormal circadian rhythm of blood pressure.

     

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