Abstract: Objective To investigate the long term impact of pregnancy-induced hypertension（PIH）on high sensitiviy C-reactive protein（hsCRP）. Methods Five hundred and twelve cases of women with PIH gave birth during October 1976to June 2006and participated the physical examination between July 2006and October 2007at Kailuan medical group were identified,and matched with 512control subjects according to the same birth-giving period（±2years old）. The hsCRP levels were determined in the two groups at the time of the physical examination. Results The follow-up time was（13.7±6.6）years. The abdominal circumference,systolic blood pressure,diastolic blood pressure before delivery were significantly higher,while gestational weeks and weight of newborn were significantly lower in PIH group than those in control group（P＜0.05）. Levels of age,follow-up time,systolic blood pressure,diastolic blood pressure,waist circumference,body mass index,total cholesterol,low density lipoprotein cholesterin,triglyceride,hsCRP during the examination were significantly higher,while high density lipoprotein cholesterin was significantly lower in PIH group than control group（P＜0.05）. The concentration of hsCRP in PIH group and control group were 0.70（0.23-2.06）mg/L,0.60（0.20-1.28）mg/L（P＜0.01）,respectively.The prevalence of hypertension,myocardial infarction and cerebral infarction were significantly higher in PIH group than those in control group（P＜0.01）.The proportion of cases of hsCRP＞3mg/L in PIH group was higher than in control group（15.0%vs 9.4%）,while the proportion of cases of hsCRP＜1mg/L in PIH group was less than in control group（58.4%vs 68.2%）,P＜0.01. With the increasing of hsCRP,the prevalence of hypertension,myocardial infarction and cerebral infarction shows the tendency of gradually increased. According to multivariate Logistic regression analysis,after adjustment for the abdominal circumference before delivery and gestational weeks,the risk of high hsCRP in PIH group was 2.46times of control group（95%CI1.43-4.24,P＜0.01）. After further adjustment for age,follow-up time,systolic blood pressure,waist circumference,body mass index,total cholesterol,triglyceride,low density lipoprotein cholesterin,high density lipoprotein cholesterin and fasting blood glucose,the risk of high hsCRP in PIH group was 1.86times of control group（95% CI 1.18-2.92,P＜0.01）.Conclusion PIH is an independent risk factor for long term high hsCRP.