Abstract: Objective To investigate the relationship between perirenal adipose tissue and blood pressure in high-fat diet-induced obese rats,and the intervention effect of angiotensinⅡ（AngⅡ）receptor antagonist（ARB）telmisartan. Methods An obese model was established in 8-week old male Wistar rats by high-fat diet administration for12 weeks. Obese rats were randomly divided into high-fat diet group and telmisartan intervention group8mg/（kg·d）,n=7. Age/weight-matched rats with normal diet were divided into blank group and control group with 8mg/（kg·d）telmisartan,n=7. Then intervention group and control group were treated with telmisartan for 20 weeks. Body weight was measured and blood pressure was monitored by tail-cuff method every week. At the end of the experiment,body weight,perirenal adipose tissue weight,serum biochemical parameters,Ang Ⅱ and aldosterone level in circulation and perirenal adipose tissue,mRNA and protein expression of angiotensin type 1receptor（AT1R）in perirenal adipose tissue were examined. Results At the end of the experiment,rats fed with high-fat diet showed abdominal obesity with elevated blood pressure and their body weight,systolic blood pressure and diastolic blood pressure were significantly higher than rats with normal diet（P＜0.05）. In high-fat diet group,the additional perirenal fat weight（0.46±0.02）vs（0.14±0.01）g/100g,the level of plasma AngⅡ（2360.0±380.7）vs（1697.9±360.7）ng/L,the expression of AT1 R protein and mRNA of perirenal fat were significantly higher than those in blank group（all P＜0.05）. Telmisartan significantly reduced body weight and perirenal fat weight of obese rats,decreased blood pressure level,reduced the level of plasma AngⅡ and the perirenal fat renin-angiotensin-aldosterone system components（RAAS）,while had no significant impact on the normal diet rats. The correlation analysis showed that additional perirenal fat weight had been obviously positive correlation with both systolic blood pressure and diastolic blood pressure（r=0.773,0.673,all P＜0.05）,and similarly,body weight and systolic blood pressure were positively correlated（r=0.628,all P＜0.05）,but body weight had no correlation with diastolic blood pressure（r=0.214,P＞0.05）. Multiple stepwise regression analysis showed that,the body wight（β=0.287）,the additional perirenal fat weight（β=0.405）,the level of Ang Ⅱin perirenal fat（β=0.324）,the level of plasma Ang Ⅱ（β=0.721）and the level of plasma aldosterone（β=0.305）were impact factors of systolic blood pressure,and the level of plasma Ang Ⅱ（β=0.529）,the additional perirenal fat weight（β=0.413）and the level of Ang Ⅱ in perirenal fat（β=0.257）were impact factors of diastolic blood pressure（all P＜0.05）.Conclusion Telmisartan might improve abnormal blood pressure induced by high-fat diet partly by reducing perirenal adipose tissue weight and suppressing local renin-angiotensin system.