原发性醛固酮增多症患者的高血压危险度分层及心脑血管合并症:北京阜外心血管病医院调查

Cardiocerebrovascular comorbidities and the risk stratification of hypertension in patients with primary aldosteronism:a survey in Fuwai Hospital

  • 摘要: 目的调查原发性醛固酮增多症(PA)患者的高血压危险度分层及心脑血管合并症的检出率。方法采用回顾性研究方法,连续入选2010年3月-2014年3月于北京阜外心血管病医院高血压中心初次住院治疗的PA患者195例,调查其高血压危险度分层及心脑血管合并症冠状动脉性心脏病(冠心病)、充血性心力衰竭、心房颤动及脑卒中检出率,比较伴或不伴心脑血管合并症患者的临床特征。结果 PA患者中高血压危险分层为高危或很高危占83.6%(163/195)。PA患者中心脑血管合并症总检出率为26.2%(51/195),其中冠心病、充血性心力衰竭、心房颤动及脑卒中的检出率分别为13.3%(26/195)、2.6%(5/195)、3.6%(7/195)、9.2%(18/195)。PA伴心脑血管合并症患者的年龄、病程、体质量指数、血清尿素氮和肌酐值以及血脂异常、糖尿病比例显著大于PA不伴心脑血管合并症患者(均P<0.05)。结论 PA患者高血压危险度分层多为高危或很高危,心脑血管合并症总检出率不容忽视。提示早期诊断和病因治疗十分重要。

     

    Abstract: Objective To investigate the risk stratification of hypertension and incidence of cardiocerebrovascular comorbidities in patients with primary aldosteronism(PA). Methods The clinical data of 195 consecutive inpatients with PA in Fuwai Hospital from March 2010 to March 2014 were collected and analyzed retrospectively. Based on2010 Chinese Hypertension Guidelines,the risk stratification of hypertension and incidence of cardiovascular comorbidities(coronary heart disease,congestive heart failure,atrial fibrillation and stroke)were assessed. The comparison of clinical characteristics was carried out between the patients with and without these cardiocerebrovascular comorbidities. Results 83.6%(163/195)of all patients included were categorized as high risk or very high risk.The ovrerall incidence of cardiovascular comorbidities was 26.2%(51/195),thereof coronary heart disease:13.3%(26/195),congestive heart failure:2.6%(5/195),atrial fibrillation:3.6%(7/195)and stroke:9.2%(18/195).The age,hypertension duration,body mass index,blood urea nitrogen,serum creatinine,hyperlipidemia and diabetes were higher in patients with comorbidities than those in patients without comorbidities(all P <0.05).Conclusion The majority of PA patients were categorized as high risk or very high risk according to the risk stratification of hypertension,and cardiocerebrovascular comorbidities were not unusual. It could be of special importance for early detection and treatment of PA.

     

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