Abstract: Objective To monitor blood pressure and blood glucose using remote wireless real-time electrocardiogram（ECG）,aiming to see whether this technique together with remote intervention guidance can increase the control rates of blood pressure and blood glucose in essential hypertensive patients complicated with type 2diabetes mellitus（T2DM）. Methods A total of 420 essential hypertensive patients with T2 DM were selected and randomly assigned to the remote monitoring（RMON）group（n=200）or the conventional control group（n=220）. All study patients underwent 24-hour ambulatory blood pressure monitoring and fasting,2-hour postprandial blood glucose measurement before formal treatment and after observation. The RMON group also underwent 72-hour continuous real-time remote wireless ECG,and simultaneous or any time monitoring of blood pressure and blood glucose during the observation period.All study patients experienced 8 weeks of blood pressure and blood glucose management,including ECG,blood pressure,blood glucose,lifestyle guide,adjustment of drug treatment,and blood pressure and blood glucose levels of these two groups were compared. Results During the 8-weeks’ management,patients in the RMON group received telematics guidance 22.7times per case on average,weekly（22.7/8）2.8times per case,and 84.5 % of patients actively called doctors for enquiring related issues. By contrast,only 17.2% of patients in the conventional control group took the initiative to contact doctors（χ2=189.42,P＜0.01）. The compliance rates of 24-hour average systolic（98.5% vs 39.1%）and diastolic blood pressure（97.5% vs 43.6%）,morning blood pressure（97.0% vs 40.5%）,fasting blood-glucose（84.0% vs 41.8%）and 2-hour postprandial blood glucose（98.0% vs 48.2%）in the RMON group were significantly higher than that in the conventional control group（all P＜0.05）. Dipper type blood pressure appeared in 98.5% of patients in the RMON group and 41.8%in the control group. The reduction of 24-hour average systolic and diastolic blood pressure was much larger in the RMON group than in the control group（52.0±11.9）vs（31.7±14.2）mm Hg,（31.0±8.2）vs（15.9±6.4）mm Hg,respectively,both P＜0.05. Conclusion The application of remote wireless real-time multi-parameter monitor in essential hypertensive patients complicated with T2 DM,together with conventional treatment could obtain real-time information and provide timely guidance,as well as draw patients’ attention to actively participate in the management of blood pressure and blood glucose.